Selective utilization of Toll-like receptor and MyD88 signaling in B cells for enhancement of the antiviral germinal center response.

نویسندگان

  • Baidong Hou
  • Philippe Saudan
  • Gary Ott
  • Matthew L Wheeler
  • Ming Ji
  • Lili Kuzmich
  • Linda M Lee
  • Robert L Coffman
  • Martin F Bachmann
  • Anthony L DeFranco
چکیده

The contribution of Toll-like receptor (TLR) signaling to T cell-dependent (TD) antibody responses was assessed by using mice lacking the TLR signaling adaptor MyD88 in individual cell types. When a soluble TLR9 ligand was used as adjuvant for a protein antigen, MyD88 was required in dendritic cells but not in B cells to enhance the TD antibody response, regardless of the inherent immunogenicity of the antigen. In contrast, a TLR9 ligand contained within a virus-like particle substantially augmented the TD germinal center IgG antibody response, and this augmentation required B cell MyD88. The ability of B cells to discriminate between antigens based on the physical form of a TLR ligand probably reflects an adaptation to facilitate strong antiviral antibody responses.

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عنوان ژورنال:
  • Immunity

دوره 34 3  شماره 

صفحات  -

تاریخ انتشار 2011